Safety analysis of gepants for migraine treatment: A pharmacovigilance study using the <scp>FDA</scp> Adverse Event Reporting System ( <scp>FAERS</scp> ) database

Gepants display distinct AE profiles, with oral agents linked to gastrointestinal and neurological effects and intranasal zavegepant associated with respiratory irritation. Continued post-marketing surveillance is essential to inform personalized migraine management and guide future CGRP-targeted drug development.

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Publication Details

Journal
Headache The Journal of Head and Face Pain
Published
2026-01-28
DOI
https://doi.org/10.1111/head.70049
Primary Topic
Migraine and Headache Studies
Type
article
Field-Weighted Citation Impact
0.00
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article

Safety analysis of gepants for migraine treatment: A pharmacovigilance study using the FDA Adverse Event Reporting System ( FAERS ) database

Yan Li, Hui Chen
Headache The Journal of Head and Face Pain
Migraine and Headache Studies
article

Safety analysis of gepants for migraine treatment: A pharmacovigilance study using the FDA Adverse Event Reporting System ( FAERS ) database

Yan Li, Hui Chen
article en

Abstract

Gepants display distinct AE profiles, with oral agents linked to gastrointestinal and neurological effects and intranasal zavegepant associated with respiratory irritation. Continued post-marketing surveillance is essential to inform personalized migraine management and guide future CGRP-targeted drug development.

Headache The Journal of Head and Face Pain
Fourth People’s Hospital of Jinan (CN)
Openalex Percentile: Top 75%
Migraine and Headache Studies
DOIOpen Access PDFOpenAlex
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Safety analysis of gepants for migraine treatment: A pharmacovigilance study using the <scp>FDA</scp> Adverse Event Reporting System ( <scp>FAERS</scp> ) database — Yan Li, Hui Chen · Headache The Journal of Head and Face Pain (2026) | TGRS Research Map | TGRS