Base-promoted deacylation of 2-acetyl-2,5-dihydrothiophenes and their oxygen-mediated hydroxylation
Solvent-dependent transformations of polysubstituted 2-acetyl-2,5-dihydrothiophenes to the corresponding 2-hydroxy- or deacetylated derivatives are described. The treatment of a methanolic solution of the dihydrothiophene substrates with sodium methoxide afforded the deacylated products. Conversely, the treatment with sodium ethoxide in an oxygen saturated ethanolic solution produced 2-hydroxy substituted 2,5-dihydrothiophenes.
Authors
- Wim Dehaen (ORCID: https://orcid.org/0000-0001-6979-5508)
- Tetyana Beryozkina (ORCID: https://orcid.org/0000-0002-9917-6748)
- Вера С. Берсенева
- Igor V. Trushkov
- Vasiliy A Bakulev
- Vladimir T Abaev
- Vladimir G Ilkin
- Margarita Likhacheva
Institutions
- Ural Federal University (RU)
- North-Caucasus Federal University (RU)
- North Ossetian State University (RU)
- N.D. Zelinsky Institute of Organic Chemistry (RU)
- KU Leuven (BE)
Publication Details
- Journal
- Beilstein Journal of Organic Chemistry
- Published
- 2026-01-28
- DOI
- https://doi.org/10.3762/bjoc.22.13
- Primary Topic
- Catalytic C–H Functionalization Methods
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Russian Science Foundation