Comparative In Vitro Evaluation of Anti-HIV Immunotoxin, Antibody–Drug Conjugate, and Radioimmunoconjugate Targeted by the Same Antibody
An IT, ADC, and RIC showed substantial differences in the degree of specific toxicity, kinetics, and mechanisms of killing. The results of this side-by-side comparison have implications for the development of CICs to treat HIV, as well as other conditions.
Authors
- Tami Peters
- Frances M. Cole
- Seth H. Pincus (ORCID: https://orcid.org/0000-0003-1622-4386)
- Brenda M. Sandmaier (ORCID: https://orcid.org/0000-0002-9767-9739)
- Donald K. Hamlin (ORCID: https://orcid.org/0009-0009-5302-8166)
- M A Stackhouse
- Anne-Sophie Kuhlmann
- Xinyi Wang
- Yawen Li
- D. Scott Wilbur
- Hans-Peter Kiem
- Robert D. Harrington
- Jasmin Martinez-Reyes
Institutions
- University of Washington (US)
- Montana State University (US)
- Fred Hutch Cancer Center (US)
Publication Details
- Journal
- Antibodies
- Published
- 2026-01-28
- DOI
- https://doi.org/10.3390/antib15010012
- Primary Topic
- Toxin Mechanisms and Immunotoxins
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Eli Lilly and Company