Use of a Cystatin C-Based GFR Equation in a Population Pharmacokinetic Model of Methotrexate Clearance in Adult Patients with Lymphoma
Our results support the use of cystatin C-inclusive glomerular filtration rate estimates in MTX pharmacokinetic modeling and suggest early MTX concentration sampling may identify AKI risk, enabling proactive, AKI-mitigating clinical interventions during HDMTX therapy.
Authors
- Carrie A. Thompson (ORCID: https://orcid.org/0000-0002-4518-2309)
- Andrew D. Rule (ORCID: https://orcid.org/0000-0003-0338-7784)
- Jason N. Barreto (ORCID: https://orcid.org/0000-0003-2146-5766)
- Erin F. Barreto (ORCID: https://orcid.org/0000-0002-0996-1487)
- Zachary L. Taylor (ORCID: https://orcid.org/0000-0001-5178-2397)
- Kristin Cole (ORCID: https://orcid.org/0000-0001-5543-5341)
- J. Kevin Hicks
- Thomas E. Witzig
- Nelson Leung
- Kianoush B. Kashani
Institutions
- Cincinnati Children's Hospital Medical Center (US)
- Children's Mercy Hospital (US)
- Mayo Clinic (US)
- Mayo Clinic in Arizona (US)
- Mayo Clinic in Florida (US)
- University of Cincinnati Medical Center (US)
Publication Details
- Journal
- Clinical Pharmacokinetics
- Published
- 2026-01-29
- DOI
- https://doi.org/10.1007/s40262-026-01618-4
- Primary Topic
- Renal Diseases and Glomerulopathies
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Institutes of Health
- National Institute of Allergy and Infectious Diseases
- National Center for Advancing Translational Sciences