Sex-specific associations between carotid plaque and bone mineral density in patients with type 2 diabetes: a retrospective cross-sectional study

Among patients with T2DM, carotid plaque was independently associated with worse osteoporosis category in women but not in men. These findings indicate sex-specific associations between carotid atherosclerosis and skeletal health; however, given the cross-sectional design and unavailable key confounders (e.g., lifestyle factors, central adiposity measures, medication patterns, and fracture outcomes), the results should be interpreted as associative and require confirmation in prospective studies.

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Publication Details

Journal
Biology of Sex Differences
Published
2026-01-28
DOI
https://doi.org/10.1186/s13293-026-00830-y
Primary Topic
Bone health and osteoporosis research
Type
article
Field-Weighted Citation Impact
0.00
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article

Sex-specific associations between carotid plaque and bone mineral density in patients with type 2 diabetes: a retrospective cross-sectional study

Qing Xue, J. Chen, Jingbo He, Hao Qi et al.
Biology of Sex Differences
Bone health and osteoporosis research
article

Sex-specific associations between carotid plaque and bone mineral density in patients with type 2 diabetes: a retrospective cross-sectional study

Qing Xue, J. Chen, Jingbo He, Hao Qi, Fei Gao, Bing Liu, Yue Liu
article en

Abstract

Among patients with T2DM, carotid plaque was independently associated with worse osteoporosis category in women but not in men. These findings indicate sex-specific associations between carotid atherosclerosis and skeletal health; however, given the cross-sectional design and unavailable key confounders (e.g., lifestyle factors, central adiposity measures, medication patterns, and fracture outcomes), the results should be interpreted as associative and require confirmation in prospective studies.

Biology of Sex DifferencesVol. 17(1)
Shanxi Medical University (CN), First Hospital of Shanxi Medical University (CN), Pudong New Area People's Hospital (CN)
Good health and well-being
Openalex Percentile: Top 75%
Bone health and osteoporosis research
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