Multi-omics characterization of RNA modification enzymes identifies NAT10 as a functionally validated prognostic biomarker in hepatocellular carcinoma

This study delineates a CNV-associated landscape of RME dysregulation across cancers and establishes a 12-RME diagnostic signature and a 6-gene prognostic model with robust predictive performance. Single-cell analyses reveal tumor- and cell-type-specific expression patterns of RMEs, while supportive functional data suggest a potential biological relevance of NAT10 in HCC. Collectively, these findings provide an association-based framework for understanding the potential roles of RNA modification programs in cancer progression and clinical stratification.