NAPQI adducts in patients with selective hypersensitivity to acetaminophen

Our findings indicate that NAPQI adduct generation is closely related to acetaminophen HSRs, supporting a mechanistic link between impaired NAPQI detoxification and acetaminophen HSR. Genetic variability in detoxifying enzymes, particularly GSTM1, may modulate individual susceptibility. These findings warrant further investigation into NAPQI adducts as predictive biomarkers for acetaminophen hypersensitivity.

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Publication Details

Journal
Frontiers in Pharmacology
Published
2026-01-28
DOI
https://doi.org/10.3389/fphar.2026.1726508
Primary Topic
Drug-Induced Adverse Reactions
Type
article
Field-Weighted Citation Impact
0.00

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article

NAPQI adducts in patients with selective hypersensitivity to acetaminophen

María de las Olas Cerezo-Arias, Pedro Ayuso, Jesús Miguel García-Menaya, José A. G. Agúndez et al.
Frontiers in Pharmacology
Drug-Induced Adverse Reactions
article

NAPQI adducts in patients with selective hypersensitivity to acetaminophen

María de las Olas Cerezo-Arias, Pedro Ayuso, Jesús Miguel García-Menaya, José A. G. Agúndez, Javier Gomez-Tabales, Antonio Silva-Rodríguez, Natalia Blanca-Lopez
article en

Abstract

Our findings indicate that NAPQI adduct generation is closely related to acetaminophen HSRs, supporting a mechanistic link between impaired NAPQI detoxification and acetaminophen HSR. Genetic variability in detoxifying enzymes, particularly GSTM1, may modulate individual susceptibility. These findings warrant further investigation into NAPQI adducts as predictive biomarkers for acetaminophen hypersensitivity.

Frontiers in PharmacologyVol. 17
Government of Extremadura (ES), Centro de Implantología Cirugía Oral y Maxilofacial (ES), Hospital Universitario Infanta Leonor (ES), Universidad de Extremadura (ES)
Junta de Extremadura, Instituto de Salud Carlos III
Good health and well-being
Openalex Percentile: Top 73%
Drug-Induced Adverse Reactions
DOIOpen Access PDFOpenAlex
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NAPQI adducts in patients with selective hypersensitivity to acetaminophen — María de las Olas Cerezo-Arias, Pedro Ayuso, et al. · Frontiers in Pharmacology (2026) | TGRS Research Map | TGRS