A meta-analysis: postoperative prophylactic antibiotics compared with non-antibiotics for pediatric hypospadias repair

This meta-analysis demonstrated that postoperative PA significantly reduced the incidence of UTI following pediatric hypospadias repair. However, no significant benefits were observed for OC, fistula, MS, sUTI, SSI, dehiscence, or diverticulum. The clinical relevance of this UTI reduction may be limited as it primarily reflects decreased asymptomatic bacteriuria rather than symptomatic infections. These findings suggest that routine postoperative PA use should be reconsidered, and individualized, risk-stratified approaches are needed.