Association Between Longitudinal Rate of Change in CSF Biomarkers and Subsequent Tau PET Burden in Early Braak Stages

These findings show that tau PET burden in Braak stage I and II subregions is associated with increases in CSF tau and p-tau over time, offering important insights into the relationships among key biomarkers for the diagnosis and staging of AD, although tau PET was collected at only a single time point, limiting inferences about the temporal evolution of PET-CSF relationships.

Authors

Martin A. Lodge (ORCID: https://orcid.org/0000-0003-0922-6519)
Kylie H. Alm
M H Miller
Daniel D. Callow (ORCID: https://orcid.org/0000-0003-0843-6602)
Jiangxia Wang (ORCID: https://orcid.org/0000-0002-1715-3981)
Nisha Rani
Anja Soldan
Arnold Bakker
Marilyn Albert
Corinne Pettigrew
Abhay Moghekar

Institutions

Johns Hopkins University (US)
Johns Hopkins Medicine (US)

Publication Details

Journal: Neurology
Published: 2026-01-28
DOI: https://doi.org/10.1212/wnl.0000000000214620
Primary Topic: Medical Imaging Techniques and Applications
Type: article
Field-Weighted Citation Impact: 0.00

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article

Association Between Longitudinal Rate of Change in CSF Biomarkers and Subsequent Tau PET Burden in Early Braak Stages

Martin A. Lodge, Kylie H. Alm, M H Miller, Daniel D. Callow et al.

Jan 28, 2026

Neurology

Medical Imaging Techniques and Applications

article

Association Between Longitudinal Rate of Change in CSF Biomarkers and Subsequent Tau PET Burden in Early Braak Stages

Martin A. Lodge, Kylie H. Alm, M H Miller, Daniel D. Callow, Jiangxia Wang, Nisha Rani, Anja Soldan, Arnold Bakker, Marilyn Albert, Corinne Pettigrew, Abhay Moghekar

January 28, 2026article en

Abstract

These findings show that tau PET burden in Braak stage I and II subregions is associated with increases in CSF tau and p-tau over time, offering important insights into the relationships among key biomarkers for the diagnosis and staging of AD, although tau PET was collected at only a single time point, limiting inferences about the temporal evolution of PET-CSF relationships.

NeurologyVol. 106(4)

Johns Hopkins University (US), Johns Hopkins Medicine (US)

Openalex Percentile: Top 75%

Medical Imaging Techniques and Applications

DOI Open Access PDF OpenAlex

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Association Between Longitudinal Rate of Change in CSF Biomarkers and Subsequent Tau PET Burden in Early Braak Stages — Martin A. Lodge, Kylie H. Alm, et al. · Neurology (2026) | TGRS Research Map | TGRS