Metformin Does Not Significantly Alter Longitudinal Dynamics of Clonal Hematopoiesis
In our cohorts, duration of metformin use among diabetic users was associated with a small reduction in CH growth rate (-0.06%/year), which is modest compared to typical DNMT3A clonal growth rates of 5-7% annually. Metformin's clinical utility for modulating clonal dynamics in real-world settings appear limited and its clinical use for this indication requires further investigation in prospective studies.
Authors
- Jason Collins
- Hind A. Beydoun (ORCID: https://orcid.org/0000-0002-9704-328X)
- Michael C. Honigberg (ORCID: https://orcid.org/0000-0001-8630-5021)
- Rachel S. Heise (ORCID: https://orcid.org/0000-0002-7785-4579)
- Siddhartha Jaiswal (ORCID: https://orcid.org/0000-0002-9597-0477)
- Liying Xue (ORCID: https://orcid.org/0009-0006-9281-4598)
- V. M. Glaser
- Jacob Otto Kitzman (ORCID: https://orcid.org/0000-0002-6145-882X)
- J. Haessler
- Alexander Reiner
- Elena Glick (ORCID: https://orcid.org/0009-0007-0949-9812)
- Yash Pershad
- Pinkal Desai
- Taralynn Mack
- Bernhard Haring
- Wodan Ling
- Pradeep Natarajan
- Aladdin Shadyab
- Eric A. Whitsel
- Alexander G. Bick
- Charles Kooperberg
- Kun Zhao
- Robert Wallace
- Caitlyn Vlasschaert
- Md Mesbah Uddin
- Eshani Pareek
- JoAnn E. Manson
Institutions
- Broad Institute (US)
- University of North Carolina at Chapel Hill (US)
- University of Iowa (US)
- University of Washington (US)
- Queen's University (CA)
- Cornell University (US)
- University of Michigan (US)
- Fred Hutch Cancer Center (US)
- Presbyterian Hospital (US)
- Iowa Department of Public Health (US)
- Human Longevity (United States) (US)
- University of Washington Applied Physics Laboratory (US)
- Department of Veterans Affairs (AU)
- University of North Carolina System (US)
- Mass General Brigham (US)
- Vanderbilt University Medical Center (US)
- Saarland University (DE)
- The University of Texas Health Science Center at Houston (US)
- Stanford University (US)
Publication Details
- Journal
- Clinical Cancer Research
- Published
- 2026-01-28
- DOI
- https://doi.org/10.1158/1078-0432.ccr-25-3606
- Primary Topic
- Metabolism, Diabetes, and Cancer
- Type
- article
- Field-Weighted Citation Impact
- 0.00