Oxidative Hetero Coupling Reaction of 2-Oxindoles with Phenols Using Guanidinium Hypoiodite Catalyst

An oxidative hetero coupling reaction between 2-oxindoles and phenols was developed using a guanidinium/hypoiodite catalytic system. This reaction enables the efficient construction of 3-aryl-2-oxindole scaffolds under mild conditions. Furthermore, oxidative heterocoupling employing a chiral guanidinium organocatalyst in combination with hypoiodite afforded enantio-enriched products with moderate enantioselectivity.