Enzymatic Disruption of the Internal Limiting Membrane Enhances Transplanted Retinal Ganglion Cell Survival
Our findings provide a translational insight on plasmin-mediated ILM disruption, demonstrating that an optimal dose can effectively degrade the mouse ILM without compromising RGC integrity, offering a promising strategy to enhance transplanted cells' survival.
Authors
- Chi‐Yu Chen (ORCID: https://orcid.org/0000-0001-9535-7341)
- Dimitrios Stavropoulos (ORCID: https://orcid.org/0009-0008-4141-3158)
- Shaohua Pi (ORCID: https://orcid.org/0000-0002-7549-8929)
- Mishal Rao (ORCID: https://orcid.org/0000-0003-2044-682X)
- Thomas V. Johnson (ORCID: https://orcid.org/0000-0002-5372-5457)
- Boris Rosin (ORCID: https://orcid.org/0000-0001-7070-0879)
- Chia-Chun Liu
- Chengcheng Zhao
- Kun-Che Chang
- José-Alain Sahel
- Niki Talebian
- Shining Wang
- Laman Mirzaliyeva
- Jung Lo
- Ya-Ling Lin
Institutions
- Johns Hopkins University (US)
- Kaohsiung Medical University (TW)
- University of Pittsburgh (US)
- Chang Gung University (TW)
- Kaohsiung Chang Gung Memorial Hospital (TW)
- UPMC Health System (US)
- University of Pittsburgh Medical Center (US)
Publication Details
- Journal
- Investigative Ophthalmology & Visual Science
- Published
- 2026-01-28
- DOI
- https://doi.org/10.1167/iovs.67.1.57
- Primary Topic
- Retinal Development and Disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00