Anti-Neuroinflammatory Potential of Drospirenone in A TLR4-Driven <i>In Vitro</i> Model of Neuropathic Pain.
Drospirenone may exhibit potential as a prophylactic agent <i>in vitro</i> during the early phases of neuroinflammation, though its efficacy appears limited in models of chronic or prolonged inflammation. These preliminary findings require <i>in vivo</i> validation, and future studies could explore possible synergistic effects with other treatments or alternative dosing strategies for neuropathic pain management.
Authors
- Leila Taheran
- Samira Rajaei (ORCID: https://orcid.org/0000-0001-8556-1525)
- Mir-Shahram Safari (ORCID: https://orcid.org/0000-0003-3330-4177)
- Ali Dabbagh (ORCID: https://orcid.org/0000-0003-4344-8131)
- Hakimeh Zali
- Mohammad Ajoudanian
Institutions
- Shahid Beheshti University (IR)
- Shahid Beheshti University of Medical Sciences (IR)
- Tehran University of Medical Sciences (IR)
Publication Details
- Journal
- PubMed
- Published
- 2025-12-07
- DOI
- https://doi.org/10.22074/cellj.2025.2049252.1758
- Primary Topic
- Pain Mechanisms and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00