The role of <i>OLE2</i> and <i>POX1-3</i> in prostaglandin E ₂ production and virulence is conserved in <i>Candidozyma</i> ( <i>Candida</i> ) <i>auris</i>

This study reveals, for the first time, that <i>Candidozyma</i> (<i>Candida auris</i>)-a growing global health threat, often causing outbreaks in hospitals-can produce a prostaglandin E₂ (PGE₂), which is known to influence how the immune system responds and has been linked to increased virulence in other yeast species. By identifying specific genes (<i>OLE2</i> and <i>POX1-3</i>) involved in PGE₂ production and virulence, potential novel drug targets have been identified. Understanding how <i>C. auris</i> produces PGE2 and how this contributes to its ability to infect and survive in hosts could lead to innovative therapies that block these pathways, making infections easier to treat.