Electroacupuncture ameliorates ulcerative colitis by suppressing ferroptosis via the JAK2/STAT3 signaling pathway
EA may alleviate ferroptosis in colonic epithelial cells by inhibiting the JAK2/STAT3 pathway, significantly reducing oxidative stress injury, improving intestinal mucosal barrier integrity, and inhibiting the DSS-induced inflammatory cascade in UC mice. This study provides important modern scientific evidence for the application of acupuncture therapy in treating gastrointestinal diseases.
Authors
- Hongkai Zhu (ORCID: https://orcid.org/0000-0002-5934-8592)
- Zhengyang Qu (ORCID: https://orcid.org/0000-0002-5453-5241)
- Laixi Ji (ORCID: https://orcid.org/0000-0002-0036-4416)
- Hong-ye Wan
- Tao Zhu
- Jing Zhang
Institutions
- Beijing University of Chinese Medicine (CN)
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Jinzhong University (CN)
- Chengdu University of Traditional Chinese Medicine (CN)
Publication Details
- Journal
- Chinese Medicine
- Published
- 2026-01-28
- DOI
- https://doi.org/10.1186/s13020-026-01337-9
- Primary Topic
- Ferroptosis and cancer prognosis
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China