Genetic and Phenotypic Associations With Sustained Antidepressant Use in Major Depressive Disorder

This study found that phenotypic factors were associated with sustained antidepressant use and treatment complexity. PGSs for traits studied were associated with treatment complexity but showed little association with sustained-use 360 groups. These findings support further research to guide treatment selection and to identify patients at risk of difficult-to-treat depression, informing precision psychiatry and early intervention in MDD.

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Publication Details

Journal
JAMA Psychiatry
Published
2026-01-28
DOI
https://doi.org/10.1001/jamapsychiatry.2025.4372
Primary Topic
Treatment of Major Depression
Type
article
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article

Genetic and Phenotypic Associations With Sustained Antidepressant Use in Major Depressive Disorder

Clara Albiñana, N. G. Martin, Maxime Taquet, Chloe X. Yap et al.
JAMA Psychiatry
Treatment of Major Depression
article

Genetic and Phenotypic Associations With Sustained Antidepressant Use in Major Depressive Disorder

Clara Albiñana, N. G. Martin, Maxime Taquet, Chloe X. Yap, Lin Tian, Alicia C. Walker, Naomi R. Wray, A. Cipriani, Enda M. Byrne, Mary Ellen Lynall, Jacob J. Crouse, Penelope A. Lind, Sarah E. Medland, Brittany L. Mitchell
article en

Abstract

This study found that phenotypic factors were associated with sustained antidepressant use and treatment complexity. PGSs for traits studied were associated with treatment complexity but showed little association with sustained-use 360 groups. These findings support further research to guide treatment selection and to identify patients at risk of difficult-to-treat depression, informing precision psychiatry and early intervention in MDD.

JAMA PsychiatryVol. 83(3)
The University of Sydney (AU), Queensland University of Technology (AU), The University of Queensland (AU), QIMR Berghofer Medical Research Institute (AU), University of Cambridge (GB), Oxford Health NHS Foundation Trust (GB), Warneford Hospital (GB), National Institute for Health and Care Research (GB), University of Oxford (GB), Mater Research (AU)
Openalex Percentile: Top 73%
Treatment of Major Depression
DOIOpen Access PDFOpenAlex
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Genetic and Phenotypic Associations With Sustained Antidepressant Use in Major Depressive Disorder — Clara Albiñana, N. G. Martin, et al. · JAMA Psychiatry (2026) | TGRS Research Map | TGRS