A Degradable Janus Adhesive Tissue Patch (JATP) for Wound Sealing and Hemostasis

Tissue adhesive patches are widely favored for their easy application, efficient wound closure, and ability to avoid secondary damage. However, postoperative repair of vital organs (e.g., the liver) requires materials with synchronous wound sealing, hemostasis, and antiadhesion functions. A biodegradable Janus Adhesive Tissue Patch (JATP) with three functional layers (antiadhesive, reinforceable, and adhesive) was fabricated. The component of the adhesive layer is a triblock copolymer prepared via free radical polymerization; poly-d,l-lactide-<i>co</i>-glycolide served as the antiadhesive layer, and Pluronic F127 as the middle layer to optimize mechanical properties and toughness. The adhesive layer formed strong covalent and hydrogen bonds with tissues, reaching an adhesion strength of >30 kPa and burst pressure of up to 60 kPa. JATP rapidly absorbed tissue moisture to form a hemostatic gel for effective sealing and hemostasis. In vivo tests confirmed its rapid adhesion, hemostasis, biodegradability, and biocompatibility, suggesting JATP is a promising biomaterial for postoperative repair with broad clinical potential.