Ginkgetin alleviates sepsis-induced acute lung injury by promoting autophagy via inhibiting ubiquitination of Laptm5 in macrophages
Our findings indicate that GK exerts its anti-inflammatory effect on macrophages by promoting autophagy via suppressing the ubiquitination of Laptm5, thus offering a promising therapeutic approach for SI-ALI.
Authors
- Y. Liu
- Ruimeng Liu (ORCID: https://orcid.org/0000-0002-6720-4660)
- Bowen Zhu (ORCID: https://orcid.org/0000-0003-2350-2735)
- Zhaoying W. Lin
- Haoxuan Liang
- Shiwei Huang
- Hongfei Hu
- Zheng Gu
- Zhiyong Peng
- Xuedi Zhang
- Qinghui Chen
- Yuetan Qiu
- Ziyi Yuan
- Yifan Deng
- Qirui Wang
Institutions
- First Affiliated Hospital of GuangXi Medical University (CN)
- Southern Medical University Shenzhen Hospital (CN)
Publication Details
- Journal
- Phytomedicine
- Published
- 2026-01-28
- DOI
- https://doi.org/10.1016/j.phymed.2026.157894
- Primary Topic
- Autophagy in Disease and Therapy
- Type
- article
- Field-Weighted Citation Impact
- 0.00