Differential cytotoxicity mechanisms of copper complexed with disulfiram for combination chemotherapy in human endometrial cancer cells

These findings indicate differential effects of CuCl and CuCl<sub>2</sub> when complexed with DSF in human endometrial cancer cells. Given the pressing need for innovative approaches to tackle endometrial cancer, we believe our findings contribute valuable insights into the molecular interactions and therapeutic potentials of DSF/copper complexes.

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Publication Details

Journal
Frontiers in Oncology
Published
2026-01-29
DOI
https://doi.org/10.3389/fonc.2026.1760903
Primary Topic
Alcohol Consumption and Health Effects
Type
article
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article

Differential cytotoxicity mechanisms of copper complexed with disulfiram for combination chemotherapy in human endometrial cancer cells

Zih-Syuan Wu, Shih‐Ming Huang, Peng-Sin Liu
Frontiers in Oncology
Alcohol Consumption and Health Effects
article

Differential cytotoxicity mechanisms of copper complexed with disulfiram for combination chemotherapy in human endometrial cancer cells

Zih-Syuan Wu, Shih‐Ming Huang, Peng-Sin Liu
article en

Abstract

These findings indicate differential effects of CuCl and CuCl<sub>2</sub> when complexed with DSF in human endometrial cancer cells. Given the pressing need for innovative approaches to tackle endometrial cancer, we believe our findings contribute valuable insights into the molecular interactions and therapeutic potentials of DSF/copper complexes.

Frontiers in OncologyVol. 16
National Defense Medical College (JP), National Defense Medical Center (TW)
Good health and well-being
Openalex Percentile: Top 75%
Alcohol Consumption and Health Effects
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