Reevaluating malaria severity metrics: insights from PfHRP2-derived biomass estimates in Ghanaian children
PfHRP2-derived total parasite biomass demonstrated a stronger association with severe malaria syndromes than peripheral parasitaemia. Accounting for prior antimalarial treatment is essential, as it may lower circulating parasite counts without affecting total biomass. Incorporating total parasite biomass assessments into clinical evaluation could enhance disease severity classification and inform timely interventions in endemic regions.
Authors
- Thomas Kwame Addison
- Dorotheah Obiri (ORCID: https://orcid.org/0000-0003-2668-3324)
- Eric Kyei‐Baafour (ORCID: https://orcid.org/0000-0001-6423-1885)
- Daniel Oduro (ORCID: https://orcid.org/0000-0003-3786-0568)
- Andrews Osei Obese
- Caleb Danso-Coffie
- Linda Eva Amoah
- Enoch Acheampong Konadu
- Kwadwo Asamoah Kusi
- Ben Gyan
Institutions
- University of Ghana (GH)
- Noguchi Memorial Institute for Medical Research (GH)
Publication Details
- Journal
- Malaria Journal
- Published
- 2026-01-28
- DOI
- https://doi.org/10.1186/s12936-026-05804-4
- Primary Topic
- Malaria Research and Control
- Type
- article
- Field-Weighted Citation Impact
- 0.00