Integrating lymphovascular and perineural invasion into TNM staging: a novel ITNM system for enhanced prognostic stratification in colorectal cancer
The ITNM system significantly enhances prognostic accuracy by integrating LVI and PNI into TNM staging, enabling risk-adapted therapeutic decision-making and representing a paradigm shift in CRC stratification.
Authors
- Y. Wang
- Jun Bu (ORCID: https://orcid.org/0000-0002-3636-6253)
- Dalin Xu
- Yang Qi
- Jiaqi Hu
- Kejin Zhu
Institutions
- North Sichuan Medical University (CN)
- Sichuan University (CN)
- West China Second University Hospital of Sichuan University (CN)
- Affiliated Hospital of North Sichuan Medical College (CN)
- Chengdu Second People's Hospital (CN)
Publication Details
- Journal
- Frontiers in Oncology
- Published
- 2026-01-28
- DOI
- https://doi.org/10.3389/fonc.2026.1745324
- Primary Topic
- Colorectal Cancer Surgical Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Chengdu Science and Technology Bureau