An Acid-Resistant Hf <sub>6</sub> -MOF for the Luminescence Sensing of Biomarkers with High Sensitivity and Selectivity

Although the detection of biomarkers epinephrine (EP) and homovanillic acid (HO) is critical for early diagnosis and personalized medicine, the development of a luminescent sensor for their precise quantification remains an ongoing challenge. In this work, a unique porous Hf<sub>6</sub>-based metal-organic framework (MOF), [Hf<sub>6</sub>(μ<sub>3</sub>-O)<sub>4</sub>(μ<sub>3</sub>-OH)<sub>4</sub>(OH)<sub>4</sub>(H<sub>2</sub>O)<sub>4</sub>(PPTA)<sub>2</sub>]·x<i>S</i> (denoted as <b>1</b>), with high acid stability was synthesized. It serves as a dual-function luminescence sensor for EP and HO detection, achieving low limits of detection of 9.3 × 10<sup>-9</sup> and 1.8 × 10<sup>-7</sup> mol/L, respectively. Besides, the thin film <b>1</b>@CRG can be simply synthesized for visual detection of EP and HO, demonstrating great potential for home-testing use. This work presents a new MOF-based sensing platform, paving the way for advanced multianalyte biomarker detection in clinical diagnostics.

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Journal
Inorganic Chemistry
Published
2026-01-28
DOI
https://doi.org/10.1021/acs.inorgchem.5c05791
Primary Topic
Metal-Organic Frameworks: Synthesis and Applications
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article
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article

An Acid-Resistant Hf 6 -MOF for the Luminescence Sensing of Biomarkers with High Sensitivity and Selectivity

X. F. Wang, Bin Zhao, Man Yu, Sheng-Li Hou et al.
Inorganic Chemistry
Metal-Organic Frameworks: Synthesis and Applications
article

An Acid-Resistant Hf 6 -MOF for the Luminescence Sensing of Biomarkers with High Sensitivity and Selectivity

X. F. Wang, Bin Zhao, Man Yu, Sheng-Li Hou, Xin-Yu Tian, Jie Dong, Xiang Xiong, Ning Wang, Yao Xie
article en

Abstract

Although the detection of biomarkers epinephrine (EP) and homovanillic acid (HO) is critical for early diagnosis and personalized medicine, the development of a luminescent sensor for their precise quantification remains an ongoing challenge. In this work, a unique porous Hf<sub>6</sub>-based metal-organic framework (MOF), [Hf<sub>6</sub>(μ<sub>3</sub>-O)<sub>4</sub>(μ<sub>3</sub>-OH)<sub>4</sub>(OH)<sub>4</sub>(H<sub>2</sub>O)<sub>4</sub>(PPTA)<sub>2</sub>]·x<i>S</i> (denoted as <b>1</b>), with high acid stability was synthesized. It serves as a dual-function luminescence sensor for EP and HO detection, achieving low limits of detection of 9.3 × 10<sup>-9</sup> and 1.8 × 10<sup>-7</sup> mol/L, respectively. Besides, the thin film <b>1</b>@CRG can be simply synthesized for visual detection of EP and HO, demonstrating great potential for home-testing use. This work presents a new MOF-based sensing platform, paving the way for advanced multianalyte biomarker detection in clinical diagnostics.

Inorganic ChemistryVol. 65(5)
Nankai University (CN), Henan University of Technology (CN), Xiamen Institute of Rare-earth Materials (CN), Advanced Energy (United States) (US), Ministry of Education (IR), Jiangxi Academy of Sciences (CN), Academy of Innovation Management (RU)
Openalex Percentile: Top 76%
Metal-Organic Frameworks: Synthesis and Applications
DOISourceOpenAlex
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An Acid-Resistant Hf <sub>6</sub> -MOF for the Luminescence Sensing of Biomarkers with High Sensitivity and Selectivity — X. F. Wang, Bin Zhao, et al. · Inorganic Chemistry (2026) | TGRS Research Map | TGRS