Integrated multi-platform metabolomics reveals fatty acid-mediated inflammatory signatures in pretibial myxedema
Our findings demonstrate that dermal fatty acid accumulation in PTM may contribute to fibroblast-mediated inflammation and fibrosis. This study provides novel insights into the metabolic-immunologic interface underlying PTM pathogenesis.
Authors
- Jiayi Cai
- Jie Zheng (ORCID: https://orcid.org/0000-0001-7932-5753)
- Han Cao (ORCID: https://orcid.org/0000-0001-9992-9108)
- Xi Chen (ORCID: https://orcid.org/0000-0002-8523-3967)
- Xia Li (ORCID: https://orcid.org/0000-0002-3977-800X)
- Xinyu Zhao (ORCID: https://orcid.org/0000-0002-5128-4424)
- Ming Pan
- Li Zhang
- Zirou Shang
- Shuoting Wang
Institutions
- Shanghai Jiao Tong University (CN)
- Ruijin Hospital (CN)
Publication Details
- Journal
- Frontiers in Endocrinology
- Published
- 2026-01-28
- DOI
- https://doi.org/10.3389/fendo.2026.1734953
- Primary Topic
- Ophthalmology and Eye Disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Natural Science Foundation of Shanghai
- National Natural Science Foundation of China