Resolving clonal evolution and selection of extrachromosomal DNA at single-cell resolution
Our study introduces a novel approach to studying ecDNA at the single-cell level, enabling both clonal evolution and transcription cell state analysis. We apply this approach to cancer samples to gain deeper insights into the role of ecDNA in intratumor heterogeneity and cellular plasticity.
Authors
- Hans Skovgaard Poulsen (ORCID: https://orcid.org/0000-0002-9801-5387)
- F. G. Rodriguez Gonzalez
- Christina Westmose Yde (ORCID: https://orcid.org/0000-0001-9578-9136)
- Balthasar Schlotmann (ORCID: https://orcid.org/0000-0002-8137-544X)
- Dorte Schou Nørøxe (ORCID: https://orcid.org/0000-0001-9921-8277)
- Alessio Locallo (ORCID: https://orcid.org/0000-0003-0977-9586)
- Ulrik Lassen
- Jane Skjøth-Rasmussen
- Joachim Weischenfeldt
Institutions
- University of Copenhagen (DK)
- Copenhagen University Hospital (DK)
- Rigshospitalet (DK)
- Danish Cancer Society (DK)
Publication Details
- Journal
- Genome biology
- Published
- 2026-01-28
- DOI
- https://doi.org/10.1186/s13059-026-03933-2
- Primary Topic
- Single-cell and spatial transcriptomics
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Novo Nordisk
- Rigshospitalet
- Novo Nordisk Fonden