LAG-3–associated CD8+ T-cell dysfunction in the cervical cancer tumor microenvironment
We confirmed that LAG-3 is highly expressed in cervical cancer tissues and is closely correlated with clinical stage, differentiation grade, lymph node metastasis, and lymphovascular space invasion. LAG-3 may inhibit the function of CD8<sup>+</sup> T cells in the cervical cancer TME, thereby promoting the progression of cervical cancer.
Authors
- G Z Zhang
- Abidan Ainiwaer (ORCID: https://orcid.org/0000-0001-6516-9171)
- Jianzhong Chen (ORCID: https://orcid.org/0000-0002-8232-7298)
- Jing Wang
- Lei Wang
- Cailing Ma
Institutions
- Xinjiang Medical University (CN)
- First Affiliated Hospital of Xinjiang Medical University (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2026-01-28
- DOI
- https://doi.org/10.3389/fimmu.2026.1750726
- Primary Topic
- Cancer Immunotherapy and Biomarkers
- Type
- article
- Field-Weighted Citation Impact
- 0.00