Photothermal therapy synergizes with CD47 blockade by inducing calreticulin exposure and remodeling the tumor extracellular matrix in oral squamous cell carcinoma
PTT synergizes with CD47 blockade primarily by inducing CRT-dependent pro-phagocytic signaling to provide the "eat me" signal. In parallel, PTT downregulates ECM components, enabling the essential "come near me" process that facilitates macrophage infiltration into tumors. This dual approach significantly improves the macrophage based anti-tumor efficacy of CD47 blockade.
Authors
- Long Cheng (ORCID: https://orcid.org/0000-0002-7084-5821)
- Wanjing Li (ORCID: https://orcid.org/0009-0006-8391-1337)
- Min Ren (ORCID: https://orcid.org/0009-0008-0053-0526)
- Xuedong Zhou (ORCID: https://orcid.org/0000-0002-9319-7302)
- Jianzhong Chen (ORCID: https://orcid.org/0000-0002-8232-7298)
- Ryohichi Sugimura
- Danrong Hu
- Tao Qin
- Quan Tang
- Lingxi Hu
- Xin Zheng
Institutions
- Sichuan University (CN)
- Sichuan Cancer Hospital (CN)
- University of Hong Kong (HK)
Publication Details
- Journal
- Cancer Immunology Immunotherapy
- Published
- 2026-01-28
- DOI
- https://doi.org/10.1007/s00262-025-04281-z
- Primary Topic
- Phagocytosis and Immune Regulation
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- China Postdoctoral Science Foundation
- Sichuan University
- Natural Science Foundation of Sichuan Province
- West China Hospital, Sichuan University