Temporal and Spatial Gene Expression Dynamics in Neonatal HI Hippocampus with Focus on Arginase
Neonatal microglia transition from early efferocytic responses to later fibrotic remodeling after HI, driven by the persistent activation of <i>PI3K-Akt</i>, <i>TGF-β</i>, and <i>Wnt/FZD4</i> pathways. These findings identify microglia as central regulators of neonatal scar formation and highlight therapeutic targets within ARG1-linked signaling.
Authors
- Donna M. Ferriero (ORCID: https://orcid.org/0000-0003-0560-9045)
- David A. Stroud (ORCID: https://orcid.org/0000-0002-2048-3383)
- M. Susan Smith (ORCID: https://orcid.org/0000-0002-3057-7009)
- Amara Larpthaveesarp (ORCID: https://orcid.org/0000-0003-4348-7069)
- Fernando F. Gonzalez (ORCID: https://orcid.org/0000-0001-5893-4592)
- Eesha Natarajan
- Thomas Arnold (ORCID: https://orcid.org/0000-0001-8295-3822)
- Cristina M. Alvira (ORCID: https://orcid.org/0000-0002-6921-0001)
- Emin Maltepe (ORCID: https://orcid.org/0000-0002-1271-7565)
- Jana Krystofova Mike (ORCID: https://orcid.org/0000-0002-0938-216X)
- Carlos Lizama-Valenzuela
- Jeffrey R. Fineman
Institutions
- University of California, San Francisco (US)
- International Drug Development (FR)
Publication Details
- Journal
- Cells
- Published
- 2026-01-28
- DOI
- https://doi.org/10.3390/cells15030253
- Primary Topic
- Neuroinflammation and Neurodegeneration Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Strong
- University of California, San Francisco