A PaDd-informed, Assay-calibrated Diagnostic Pathway for Suspected Pulmonary Embolism in Older Adults: From Signal to Strategy
To the Editor: We commend Cohen et al. for introducing a prag-matic composite—Padua score × D-dimer (PaDd)—designed to refine pulmonary embolism (PE) exclusion in adults aged ≥65 years, a population often characterized by multimorbidity, physiological heterogeneity, and atypical presentations. Their single-center retrospective cohort (2021–2023) provides a compelling, hypothesis-generating signal: combining a validated venous thromboembolism risk score with D-dimer may enhance specificity without compromising safety.
Authors
- Mulavagili Vijayasimha (ORCID: https://orcid.org/0000-0003-2038-7006)
- Sivaji Adusumalli
Institutions
- Chandigarh University (IN)
- Acharya Nagarjuna University (IN)
Publication Details
- Journal
- Rambam Maimonides Medical Journal
- Published
- 2026-01-28
- DOI
- https://doi.org/10.5041/rmmj.10568
- Primary Topic
- Venous Thromboembolism Diagnosis and Management
- Type
- article
- Field-Weighted Citation Impact
- 0.00