Intratumoral heterogeneity and chemotherapy-induced alteration of CLDN18.2 expression in resectable gastric cancer
The CLDN18.2 expression demonstrated an acceptable concordance between biopsy and surgically resected specimens. However, high prevalence of heterogeneous expression and tendency for CLDN18.2 positivity to shift to negativity following chemotherapy existed.
Authors
- Kotaro Yamashita (ORCID: https://orcid.org/0000-0001-9538-5705)
- Yuichiro Doki
- Yuichi Motoyama
- Takeshi Takahashi (ORCID: https://orcid.org/0000-0002-6477-7770)
- Kenichi Nakajima (ORCID: https://orcid.org/0000-0001-7188-8746)
- Yukinori Kurokawa (ORCID: https://orcid.org/0000-0002-2883-0132)
- Eiichi Morii (ORCID: https://orcid.org/0000-0001-8490-3650)
- Tomoki Makino (ORCID: https://orcid.org/0000-0001-7918-4217)
- Hidetoshi Eguchi (ORCID: https://orcid.org/0000-0002-2318-1129)
- Kota Momose
- Takuro Saito
- Takaomi Hagi
- Shinnosuke Nagano
- Koji Tanaka
Institutions
- The University of Osaka (JP)
Publication Details
- Journal
- International Journal of Clinical Oncology
- Published
- 2026-01-28
- DOI
- https://doi.org/10.1007/s10147-026-02972-w
- Primary Topic
- Barrier Structure and Function Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00