Toddalia asiatica (L.) Lam. induces apoptosis in rheumatoid arthritis fibroblast-like synoviocytes by modulating the PI3K/AKT/NF-κB pathway
TA exerts anti-RA effects by inhibiting the PI3K/AKT/NF-κB pathways and modulating the apoptosis balance of synovial fibroblasts. These findings provide a theoretical foundation for the clinical application of TA in RA treatment.
Authors
- YiHui Chai
- Chunyan Liu (ORCID: https://orcid.org/0000-0002-3299-1115)
- Jianjun Niu
- Zhiliang Fan
- Fanyong Zeng
- Chaocao Yan
- Huanzhen Wang
Institutions
- Guizhou University (CN)
- Hangzhou Hospital of Traditional Chinese Medicine (CN)
Publication Details
- Journal
- Molecular Immunology
- Published
- 2026-01-29
- DOI
- https://doi.org/10.1016/j.molimm.2026.01.008
- Citations
- 1
- Primary Topic
- Rheumatoid Arthritis Research and Therapies
- Type
- article
- Field-Weighted Citation Impact
- 46.80