Apigenin ameliorates postoperative inflammation and accelerates wound healing in a rat model of perianal abscess by targeting the JAK1/STAT3 pathway in macrophages
Apigenin may contribute to observed biological effects of CJO that promotes wound healing by attenuating macrophage-driven inflammation through potential modulation of the JAK1/STAT3 signaling pathway, offering a promising natural immunomodulator for postoperative wound management.
Authors
- Xuelong Zhao
- Jiahui Ren
- Ruixue Dai (ORCID: https://orcid.org/0000-0002-3703-0153)
- Cao Liangliang
- Peidong Chen
- Beihua Bao
- Weifeng Yao
- Jingru Liu
- Li Zhang
- Kexin Zhu
Institutions
- Nanjing University of Chinese Medicine (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2026-01-28
- DOI
- https://doi.org/10.3389/fimmu.2026.1726917
- Primary Topic
- Anorectal Disease Treatments and Outcomes
- Type
- article
- Field-Weighted Citation Impact
- 0.00