Discordance of Dopaminergic Dysfunction and Subcortical Atrophy by α‐Synuclein Status in Sporadic and Genetic Parkinson's Disease
S+ patients exhibit more dopaminergic deficit, whereas S- patients have more subcortical atrophy across sporadic and genetic PD. Together, our findings reveal structure/function and DAT/MRI discordance, providing insight into biomarkers and pathophysiology of synucleinopathy and PD. © 2026 The Author(s). Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.
Authors
- Ilya M. Nasrallah (ORCID: https://orcid.org/0000-0003-2346-7562)
- Jacob G. Dubroff (ORCID: https://orcid.org/0000-0002-0732-2374)
- Long Xie
- Michael Tran Duong (ORCID: https://orcid.org/0000-0003-0312-5530)
- Joaquin A. Vizcarra
- Pulkit Khandelwal
- Paul A. Yushkevich
- Andrew Siderowf
- Parkinson's Progression Markers Initiative
- Yue Li
- Sandhitsu R. Das
- David A. Wolk
Institutions
- TiGenix (Spain) (ES)
- University of Pennsylvania (US)
Publication Details
- Journal
- Movement Disorders
- Published
- 2026-01-28
- DOI
- https://doi.org/10.1002/mds.70186
- Citations
- 1
- Primary Topic
- Parkinson's Disease Mechanisms and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 39.15
Funders
- Michael J. Fox Foundation for Parkinson's Research
- Bristol-Myers Squibb
- Biogen
- Celgene
- University of Pennsylvania
- Institute for Translational Medicine and Therapeutics
- Allergan
- Avid Radiopharmaceuticals
- National Institute on Aging