T‐Cell Signaling Pathways, Including Exhaustion, Predominate in Unhealthy Visceral and Subcutaneous Adipose Tissues
T-cell signaling and exhaustion predominate in metabolically unhealthy adaptations of both SAT and VAT. This novel handling of transcript data using an unbiased clustering approach and the creation of continuous MetS scores lead to new insights regarding adipose depot responses and T-cell biology.
Authors
- Kylie Kavanagh (ORCID: https://orcid.org/0000-0001-8772-6186)
- Alistaire D. Ruggiero (ORCID: https://orcid.org/0000-0002-1942-2751)
- Laura A. Cox
- Sobha Puppala
- Christina M. Stevens
- Alyssa R. Hamann
Institutions
- University of Tasmania (AU)
- Wake Forest University (US)
Publication Details
- Journal
- Obesity
- Published
- 2026-01-28
- DOI
- https://doi.org/10.1002/oby.70133
- Primary Topic
- Adipokines, Inflammation, and Metabolic Diseases
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Comprehensive Cancer Center at Wake Forest Baptist Medical Center
- National Institutes of Health
- National Cancer Institute