Multi-omics analyses related to unfolded protein response in prostate cancer implicate pro-tumor role of IFRD1
We provide the first systematic single-cell atlas of UPR heterogeneity in PCa and develop a clinically translatable UPRRS prognostic model. IFRD1, a key driver, emerges as a dual diagnostic and therapeutic target, offering both theoretical and experimental foundations for precision stratification and individualized management of PCa.
Authors
- Wei Zhang (ORCID: https://orcid.org/0000-0002-6190-3129)
- Yanrong Qian
- W Chen
- Dakun Zhang (ORCID: https://orcid.org/0000-0002-4308-5900)
- Shengrong Chen
- HuiXing Chen
- Chunyan Chu
- Fan Shi
- Caichen Luo
- Fan Yunxia
- Enyao Huang
- Yifei Cheng
- Tiange Wu
- Yifeng Xue
- Ping Wang
Institutions
- Jiangsu University (CN)
- Shanghai Jiao Tong University (CN)
- Southeast University (BD)
- Zhongda Hospital Southeast University (CN)
- Jintan People's Hospital (CN)
- Shanghai First People's Hospital (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2026-01-29
- DOI
- https://doi.org/10.3389/fimmu.2026.1744197
- Primary Topic
- Ferroptosis and cancer prognosis
- Type
- article
- Field-Weighted Citation Impact
- 0.00