Characterizing mouse platelet heterogeneity across diverse disease models using spectral flow cytometry and high-dimensional analysis
This integrated and scalable workflow provides a robust platform for investigating disease-associated changes in platelet heterogeneity. The PlateletProfiler pipeline is compatible with both mouse and human datasets, supporting broad experimental and translational applications.
Authors
- Elisabeth M. Battinelli (ORCID: https://orcid.org/0000-0003-1916-047X)
- Rebecca L. Zon (ORCID: https://orcid.org/0000-0002-6980-5996)
- Harvey G. Roweth (ORCID: https://orcid.org/0000-0002-1100-8409)
- Margaret Smith (ORCID: https://orcid.org/0000-0002-3523-7150)
- Emily M. Clarke
- Deepa Gautam
- Megan E. Sullivan
- Avinash Kumar
- Panagiotis Karagiannis
Institutions
- Brigham and Women's Hospital (US)
- Harvard University (US)
- SdPhotonics (United States) (US)
- Dana-Farber Cancer Institute (US)
- University of Reading (GB)
Publication Details
- Journal
- Research and Practice in Thrombosis and Haemostasis
- Published
- 2026-01-28
- DOI
- https://doi.org/10.1016/j.rpth.2026.103371
- Primary Topic
- Platelet Disorders and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00