No Association Between Autism Spectrum Disorder and Mitochondrial DNA Variants: A Comprehensive Genetic Study in Trakya Population
Through comprehensive mtDNA scanning and rigorous pathogenicity assessment, our findings suggest that mtDNA variations are not implicated in the pathogenesis of ASD. However, given the complex nature of ASD, future research is needed with larger sample sizes, standardized pathogenicity assessment criteria and detailed phenotypic analyses to further elucidate the relationship between mtDNA variants and ASD.
Authors
- Hasan Cem Aykutlu (ORCID: https://orcid.org/0000-0002-4809-4857)
- H. Hakan Gürkan (ORCID: https://orcid.org/0000-0001-7373-8733)
- Hazal Sezginer Guler
- Leyla Bozatlı
- Engin Atlı
- Işık Görker
- Cansu Çınar
- Ayhan Kütükçü
Institutions
- Trakya University (TR)
- Sakarya Eğitim ve Araştırma Hastanesi (TR)
Publication Details
- Journal
- International Journal of Developmental Neuroscience
- Published
- 2026-01-28
- DOI
- https://doi.org/10.1002/jdn.70100
- Primary Topic
- Mitochondrial Function and Pathology
- Type
- article
- Field-Weighted Citation Impact
- 0.00