Amygdala-centered mechanisms of pain amplification and chronification in fibromyalgia and migraine: Narrative review
The amygdala emerges as a key integrative node linking nociceptive, emotional, and autonomic processes in fibromyalgia and migraine. Through its influence on descending pain modulatory systems, amygdala-centered circuits play a critical role in pain chronification and affective sensitization. These findings support a circuit-based framework for chronic pain, highlighting the amygdala as a promising target for individualized, multimodal therapeutic strategies aimed at restoring adaptive emotional-nociceptive integration.
Authors
- S. Zh. Antonyan (ORCID: https://orcid.org/0000-0003-1463-1244)
- В. И. Тарасенко (ORCID: https://orcid.org/0000-0001-8208-6941)
- Nataliya Zharova (ORCID: https://orcid.org/0000-0003-2495-6923)
- Denis Aniskin (ORCID: https://orcid.org/0000-0003-2764-8571)
- Yury O Zharikov
- Sergey N. Ryagin
- T. S. Zharikova
- André Pontes-Silva
- Vladimir Nikolenko
- Elena Alekseevna Mikliaeva
- Anastasia Mchenskaya
- Yane Pelicer-Marques
Institutions
- Universidade Federal de São Carlos (BR)
- Sechenov University (RU)
- Department of Public Health (AS)
- Research Institute of Emergency Care (RU)
- Moscow University «Synergy» (RU)
Publication Details
- Journal
- Behavioural Brain Research
- Published
- 2026-01-28
- DOI
- https://doi.org/10.1016/j.bbr.2026.116071
- Citations
- 1
- Primary Topic
- Pain Mechanisms and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 32.84