Global research landscape and multisystem health mechanisms of luteolin: a comprehensive bibliometric and network pharmacology study
Luteolin research exhibits sustained growth, with a significant increase after 2021. Research focus has expanded from early antioxidant and anti-inflammatory mechanisms to metabolic health, immune regulation, tumor suppression, and multisystem protection. Network pharmacology identified 239 potential targets, with core targets including TP53, TNF, STAT3, and EGFR, significantly enriched in p53, PI3K-Akt, TNF, and IL-17 pathways. Disease association networks indicate luteolin's potential to intervene in neurological, circulatory, metabolic, immune, digestive, respiratory disorders, and multiple tumors, exhibiting typical multi-target comprehensive regulatory characteristics.
Authors
- Zhongxun Li (ORCID: https://orcid.org/0000-0001-5692-3697)
- Yujia Guo (ORCID: https://orcid.org/0000-0002-2009-2286)
- Xin Wen (ORCID: https://orcid.org/0000-0002-4549-0547)
- Han Qh
- Xin Guan (ORCID: https://orcid.org/0000-0002-6244-2176)
- Huina Guo
- Haiyan Wang (ORCID: https://orcid.org/0000-0001-7918-6765)
- Kexin Wang (ORCID: https://orcid.org/0000-0002-8541-7512)
- Liting Zhao
- Ying Wang
- Xiyan Tian
- Bohui Wu
- Chunming Zhang
Institutions
- Shanxi Medical University (CN)
- QT Ultrasound (United States) (US)
- First Hospital of Shanxi Medical University (CN)
Publication Details
- Journal
- Frontiers in Nutrition
- Published
- 2026-01-28
- DOI
- https://doi.org/10.3389/fnut.2026.1758832
- Primary Topic
- Atherosclerosis and Cardiovascular Diseases
- Type
- article
- Field-Weighted Citation Impact
- 0.00