Transscleral photodynamic therapy with a chlorin e6: An experimental study of exposure parameters and therapeutic window

TSPDT with chlorin e6 enables selective targeting of intraocular pathological tissues while preserving scleral and retinal integrity. Defining the therapeutic window and using real-time thermal monitoring enhances treatment safety. These findings lay a foundation for clinical protocols for uveal melanoma and other intraocular tumors.

Authors

Institutions

Publication Details

Journal
PLoS ONE
Published
2026-01-28
DOI
https://doi.org/10.1371/journal.pone.0341058
Primary Topic
Photodynamic Therapy Research Studies
Type
article
Field-Weighted Citation Impact
0.00

Funders

Controls
|||
ALL TIME
JAN
FEB
MAR
APR
MAY
JUN
JUL
AUG
SEP
OCT
article

Transscleral photodynamic therapy with a chlorin e6: An experimental study of exposure parameters and therapeutic window

V. G. Gvazava, Sergey Vorobyev, Elena V. Samkovich, Sergey B. Shevchenko et al.
PLoS ONE
Photodynamic Therapy Research Studies
article

Transscleral photodynamic therapy with a chlorin e6: An experimental study of exposure parameters and therapeutic window

V. G. Gvazava, Sergey Vorobyev, Elena V. Samkovich, Sergey B. Shevchenko, Alexander A. Ivanov, Irina E. Panova, Elizaveta A. Masian, Elizaveta S. Kalashnikova, Ernest V. Boiko, Alexandra E. Kim
article en

Abstract

TSPDT with chlorin e6 enables selective targeting of intraocular pathological tissues while preserving scleral and retinal integrity. Defining the therapeutic window and using real-time thermal monitoring enhances treatment safety. These findings lay a foundation for clinical protocols for uveal melanoma and other intraocular tumors.

PLoS ONEVol. 21(1)
St Petersburg University (RU), Morpho (United States) (US), Saint-Petersburg Medico-Social Institute (RU), Institute of Experimental Medicine (RU), Intersectoral Research and Technology Complex Eye Microsurgery (RU), North-Western State Medical University named after I.I. Mechnikov (RU)
Russian Science Foundation
Good health and well-being
Openalex Percentile: Top 76%
Photodynamic Therapy Research Studies
DOIOpen Access PDFOpenAlex
AI Navigator

Ask Laika to Summarize, Analyze, and Connect papers live on the map.

Summarize Papers & Methodologies

Extract key findings, datasets, and comparative methods across publications.

Benchmark Rankings & Visual Analytics

Rank top research institutions, authors, funders, topics, and journals by Field-Weighted Citation Impact (FWCI) and paper volume with instant charts.

Connect Distant Disciplines

Bridge topological clusters on the map to find hidden collaborative intersections.

Transscleral photodynamic therapy with a chlorin e6: An experimental study of exposure parameters and therapeutic window — V. G. Gvazava, Sergey Vorobyev, et al. · PLoS ONE (2026) | TGRS Research Map | TGRS