Liver iron levels are associated with HFE-hemochromatosis genotype, diet, adiposity, and disease in the UK Biobank
Undiagnosed C282Y+/+ individuals had excess liver iron versus diagnosed, likely due to treatment. Genetic and environmental factors influence liver iron beyond C282Y+/+. Tailored lifestyle advice could benefit those at risk of hemochromatosis.
Authors
- Mitchell R. Lucas (ORCID: https://orcid.org/0000-0003-0351-4608)
- Janice L. Atkins (ORCID: https://orcid.org/0000-0003-4919-9068)
- João Delgado (ORCID: https://orcid.org/0000-0003-1648-871X)
- Katharine Hutchison (ORCID: https://orcid.org/0000-0003-4102-4474)
- Luke C. Pilling
- Jeremy D. Shearman
- Daniel S. Williamson
Institutions
- University of Exeter (GB)
- Royal Devon & Exeter NHS Foundation Trust (GB)
- South Warwickshire NHS Foundation Trust (GB)
Publication Details
- Journal
- Hepatology Communications
- Published
- 2026-01-28
- DOI
- https://doi.org/10.1097/hc9.0000000000000883
- Primary Topic
- Iron Metabolism and Disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00