The combination of visceral adiposity and triglyceride-glucose indices as predictors of cardiovascular disease incidence in middle-aged and older adults
The integration of TyG with anthropometric indices strengthened its association with CVD incidence. While TyG-WWI and TyG-ConI exhibited the highest predictive ability in the CHARLS and MESA cohorts, respectively, TyG-WHtR consistently yielded the greatest improvement to traditional risk models. Elevated BP levels partially mediated this association. Early intervention targeting visceral adiposity and impaired insulin sensitivity is crucial for mitigating CVD incidence in middle-aged and older adults.
Authors
- Xiaodong Li (ORCID: https://orcid.org/0000-0003-2348-926X)
- Jiawei Zhang (ORCID: https://orcid.org/0000-0001-5270-9562)
- Zhipeng Hu (ORCID: https://orcid.org/0000-0003-1524-6452)
- Yan Yin
- Xu Li
- Lili Wang
- Yanguang Li
- Shangqiu Ning
- Xu Liu
- Ran Xiong
- Yunlong Wang
- Qiaoyuan Li
Institutions
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Beijing Anzhen Hospital (CN)
- Fu Wai Hospital (CN)
Publication Details
- Journal
- European journal of medical research
- Published
- 2026-01-28
- DOI
- https://doi.org/10.1186/s40001-026-03907-x
- Primary Topic
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Type
- article
- Field-Weighted Citation Impact
- 0.00