Circulating Mitochondrial Transfer Carrying Dihydroorotate Dehydrogenase Reduces Oxidative Cell Death in Prolonged Cold-induced Cardiac Reperfusion Injury in Heart Transplantation
DHODH-CT-Mito overcomes exogenous DHODH limits, providing durable mitochondrial activity, suppressing ferroptosis, and preserving graft function with low risk-offering a translatable strategy for donor heart preservation.
Authors
- Chengzhi Han (ORCID: https://orcid.org/0000-0003-2894-8699)
- Fanshun Wang
- C. Wang
- Zhaohua Yang (ORCID: https://orcid.org/0000-0002-2824-3560)
- Shutian Zhang
- Yijun Huang
- Maoxiang Chen
- Dajun Zhao
- Shouguo Yang
Institutions
- Sun Yat-sen University (CN)
- Fudan University (CN)
- Zhongshan Hospital (CN)
- The First Affiliated Hospital, Sun Yat-sen University (CN)
- Shanghai Institute of Hematology (CN)
Publication Details
- Journal
- Transplantation
- Published
- 2026-01-28
- DOI
- https://doi.org/10.1097/tp.0000000000005622
- Citations
- 1
- Primary Topic
- Biochemical and Molecular Research
- Type
- article
- Field-Weighted Citation Impact
- 22.24