High‐throughput single‐cell DNA methylation and chromatin accessibility co‐profiling with SpliCOOL‐seq
SpliCOOL-seq achieves high-throughput single-cell co-profiling of DNA methylation and chromatin accessibility. DNMT inhibitors caused cancer cell demethylation with divergent patterns. SpliCOOL-seq enables the discovery of genes related to LUAD tumorigenesis. Ageing and LUAD tumorigenesis may share similar epigenetic alterations.
Authors
- Qingmei Shen
- Enze Deng
- Ling Luo (ORCID: https://orcid.org/0000-0002-4091-0450)
- Jing Zhang (ORCID: https://orcid.org/0000-0003-3064-7625)
- Xiaoying Fan
- Qifeng Yang
- Dan Su
Institutions
- Sun Yat-sen University (CN)
- Guangzhou Experimental Station (CN)
- Second Affiliated Hospital of Guangzhou Medical University (CN)
- Guangzhou Regenerative Medicine and Health Guangdong Laboratory (CN)
- Guangzhou Medical University (CN)
Publication Details
- Journal
- Clinical and Translational Medicine
- Published
- 2026-01-28
- DOI
- https://doi.org/10.1002/ctm2.70584
- Primary Topic
- Epigenetics and DNA Methylation
- Type
- article
- Field-Weighted Citation Impact
- 0.00