Pathologic response and safety of preoperative treatment regimens in gastric cancer undergoing D2 gastrectomy: a real-world cohort study
Preoperative treatment regimens containing immunotherapy, particularly the triple combination, improved pathological response without increasing preoperative risk. Tumor biology-especially Lauren subtype and PD-L1 expression-had a greater impact on response than regimen intensity, supporting biomarker-guided strategies.
Authors
- Jiwu GUO
- N. Li
- Jie Mao (ORCID: https://orcid.org/0000-0003-3068-7504)
- Ziyuan Mou
- Jizhen Wang
- Penghui Liu
- Gengyutong Zhao
Institutions
- Lanzhou University Second Hospital (CN)
- Lanzhou University (CN)
- Universidad del Noreste (MX)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2026-01-29
- DOI
- https://doi.org/10.3389/fimmu.2026.1766793
- Primary Topic
- Gastric Cancer Management and Outcomes
- Type
- article
- Field-Weighted Citation Impact
- 0.00