Editorial: Improving understanding and treatment of peripheral positional vertigo (PPV)

arise from patient-specific factors like age. Li et al. (3) study depicted that elderly patients with presence of atypical symptoms of PPPV experience delays in diagnosis compared with younger individuals. Their findings describe how comorbidities may conceal the classical positional triggers of PPPV in aging populations. In fact, it is now advocated by The World Falls Guidelines: all older adults (>60 years) with objective or subjective balance problems, irrespective of symptomatic complaint, should have positional testing to examine for PPPV (4) .A retrospective study conducted by Lu et al. (5) , showed that timing of clinical assessment of BPPV appeared to be a key component of diagnostic variability. Their study demonstrated that positional tests yield a significantly higher rate of positive diagnostic findings in the morning compared with the afternoon. This is theoretically logical because it its assumed that the crystals form a agglomerate overnight while resting which has a higher impact on endolymphatic flow than single crystals (6) . Clinicians should therefore consider the timing of testing during the day, particularly in patients with fluctuating symptoms.Variability in head orientation and movement during positional manoeuvres also introduces significant diagnostic uncertainty (7) . Even minor deviations from standardized head positions can alter the intensity and direction of nystagmus by modifying canal stimulation, thereby reducing diagnostic accuracy. Simulation studies further demonstrate that both the initial position of otolithic debris and the sequence of positional testing can influence nystagmus direction and lead to altered interpretations of positional tests (8) . Consistent with these findings, substantial variability in head angulation during commonly performed manoeuvres such as the Epley manoeuvre has been documented, potentially contributing to inconsistent diagnostic and therapeutic outcomes (9) . Collectively, these data underscore the critical role of precise technique, namely orientation of the canal tested in relation to the gravitational vector, test sequencing (one should begin with the horizontal canals, then posterior and finally the anterior (10) and objective guidance in optimizing the reliability of positional testing.Complementing these observations, Zuma e Maia et al. (11) provided a neurophysiological perspective on horizontal canal PPPV (HC-PPPV) by emphasizing that correct side for manoeuvre selection is essential for effective treatment. In cases where the Supine Roll Test (SRT) shows minimal differences in nystagmus intensity, their algorithm combines SRT variant identification (geotropic vs. apogeotropic) with Bow-and Lean-Test responses. In practice, bowing identifies the affected side in geotropic HC-PPPV, whereas leaning does so in apogeotropic cases. Combining the results of both test findings using videooculography recordings can enhance diagnostic results.Xing et al. (12) highlight diet as a modifiable risk factor in PPPV, proposing that dietary patterns may influence inner-ear health via antioxidant effects, improved microcirculation, and metabolic regulation. Genetic variability likely modulates these effects, as differences in genes related to otoconial integrity, vestibular function, and metabolism may alter dietary response and PPPV susceptibility and prognosis.Collectively, a web of interacting factors influences outcomes in PPPV like patient demographics, comorbidities, the timing of assessment and the precision of clinical maneuvers.Rather than viewing these findings as separate observations, they should be considered as overlapping pieces of a broader clinical picture. By integrating these perspectives, it helps clinicians to refine diagnostic strategies, anticipate sources of variability, and better adapt care to individual patients.Going forward, several avenues merit focused exploration. Prospective studies examining how systemic health, otoconial stability, and canal biomechanics relate to symptom variability may clarify why some patients deviate from expected patterns. Efforts to improve diagnostic consistency-through enhanced manoeuvre training, supportive positioning technologies, or optimized testing workflows-may help improve reproducibility. Further, dedicated investigations in older adults and patients with comorbidities, namely any other inner ear diseases, remain essential, as these groups often present with atypical or muted manifestations that challenge conventional diagnostic assumptions.Taken together, these perspectives highlight the evolving understanding of why PPPV, though common, is not uniformly straightforward to evaluate. Integrating physiological insights with practical clinical considerations can support more precise, patient-centered diagnostic approaches and ultimately improve outcomes for individuals with positional vertigo.Finally, from a pragmatic clinical point of view every patient with vertigo or dizziness -independent of patient history -should be examined for with the correct orientation of the canal examined relative to gravitational vector during every visit not to overlook this welltreatable most frequent peripheral vestibular disease; one should begin with the diagnostic manoeuvres for horizontal, then posterior and finally anterior canals; and every patient needs follow-up examinations to check the efficacy of the specific treatment manoeuvres.

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Journal
Frontiers in Neurology
Published
2026-01-28
DOI
https://doi.org/10.3389/fneur.2025.1773353
Primary Topic
Vestibular and auditory disorders
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article
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article

Editorial: Improving understanding and treatment of peripheral positional vertigo (PPV)

Norberto Martinez, Francisco Carlos Zuma e Maia, Michael Strupp, Anita Bhandari
Frontiers in Neurology
Vestibular and auditory disorders
article

Editorial: Improving understanding and treatment of peripheral positional vertigo (PPV)

Norberto Martinez, Francisco Carlos Zuma e Maia, Michael Strupp, Anita Bhandari
article en

Abstract

arise from patient-specific factors like age. Li et al. (3) study depicted that elderly patients with presence of atypical symptoms of PPPV experience delays in diagnosis compared with younger individuals. Their findings describe how comorbidities may conceal the classical positional triggers of PPPV in aging populations. In fact, it is now advocated by The World Falls Guidelines: all older adults (>60 years) with objective or subjective balance problems, irrespective of symptomatic complaint, should have positional testing to examine for PPPV (4) .A retrospective study conducted by Lu et al. (5) , showed that timing of clinical assessment of BPPV appeared to be a key component of diagnostic variability. Their study demonstrated that positional tests yield a significantly higher rate of positive diagnostic findings in the morning compared with the afternoon. This is theoretically logical because it its assumed that the crystals form a agglomerate overnight while resting which has a higher impact on endolymphatic flow than single crystals (6) . Clinicians should therefore consider the timing of testing during the day, particularly in patients with fluctuating symptoms.Variability in head orientation and movement during positional manoeuvres also introduces significant diagnostic uncertainty (7) . Even minor deviations from standardized head positions can alter the intensity and direction of nystagmus by modifying canal stimulation, thereby reducing diagnostic accuracy. Simulation studies further demonstrate that both the initial position of otolithic debris and the sequence of positional testing can influence nystagmus direction and lead to altered interpretations of positional tests (8) . Consistent with these findings, substantial variability in head angulation during commonly performed manoeuvres such as the Epley manoeuvre has been documented, potentially contributing to inconsistent diagnostic and therapeutic outcomes (9) . Collectively, these data underscore the critical role of precise technique, namely orientation of the canal tested in relation to the gravitational vector, test sequencing (one should begin with the horizontal canals, then posterior and finally the anterior (10) and objective guidance in optimizing the reliability of positional testing.Complementing these observations, Zuma e Maia et al. (11) provided a neurophysiological perspective on horizontal canal PPPV (HC-PPPV) by emphasizing that correct side for manoeuvre selection is essential for effective treatment. In cases where the Supine Roll Test (SRT) shows minimal differences in nystagmus intensity, their algorithm combines SRT variant identification (geotropic vs. apogeotropic) with Bow-and Lean-Test responses. In practice, bowing identifies the affected side in geotropic HC-PPPV, whereas leaning does so in apogeotropic cases. Combining the results of both test findings using videooculography recordings can enhance diagnostic results.Xing et al. (12) highlight diet as a modifiable risk factor in PPPV, proposing that dietary patterns may influence inner-ear health via antioxidant effects, improved microcirculation, and metabolic regulation. Genetic variability likely modulates these effects, as differences in genes related to otoconial integrity, vestibular function, and metabolism may alter dietary response and PPPV susceptibility and prognosis.Collectively, a web of interacting factors influences outcomes in PPPV like patient demographics, comorbidities, the timing of assessment and the precision of clinical maneuvers.Rather than viewing these findings as separate observations, they should be considered as overlapping pieces of a broader clinical picture. By integrating these perspectives, it helps clinicians to refine diagnostic strategies, anticipate sources of variability, and better adapt care to individual patients.Going forward, several avenues merit focused exploration. Prospective studies examining how systemic health, otoconial stability, and canal biomechanics relate to symptom variability may clarify why some patients deviate from expected patterns. Efforts to improve diagnostic consistency-through enhanced manoeuvre training, supportive positioning technologies, or optimized testing workflows-may help improve reproducibility. Further, dedicated investigations in older adults and patients with comorbidities, namely any other inner ear diseases, remain essential, as these groups often present with atypical or muted manifestations that challenge conventional diagnostic assumptions.Taken together, these perspectives highlight the evolving understanding of why PPPV, though common, is not uniformly straightforward to evaluate. Integrating physiological insights with practical clinical considerations can support more precise, patient-centered diagnostic approaches and ultimately improve outcomes for individuals with positional vertigo.Finally, from a pragmatic clinical point of view every patient with vertigo or dizziness -independent of patient history -should be examined for with the correct orientation of the canal examined relative to gravitational vector during every visit not to overlook this welltreatable most frequent peripheral vestibular disease; one should begin with the diagnostic manoeuvres for horizontal, then posterior and finally anterior canals; and every patient needs follow-up examinations to check the efficacy of the specific treatment manoeuvres.

Frontiers in NeurologyVol. 16
Universidad Santo Tomás (CO), Mahatma Gandhi University (RW), Pontifícia Universidade Católica do Rio Grande do Sul (BR), Ludwig-Maximilians-Universität München (DE), University of Santo Tomas (PH)
Openalex Percentile: Top 80%
Vestibular and auditory disorders
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