Effects of Immune Cells and Plasma Metabolites on Osteoarthritis: A Mediation Mendelian Randomization Study
Our study revealed a substantial impact of specific immune cell phenotypes and plasma metabolites on the progression of osteoarthritis, enhancing the understanding of the complex interplay between immunity and metabolism in osteoarthritis pathogenesis. Further research is necessary to clarify the underlying mechanisms driving these associations.
Authors
- Huitian Han
- Changfa Huang
- Xuemeng Mu (ORCID: https://orcid.org/0000-0002-7162-721X)
- H. Christina Fan (ORCID: https://orcid.org/0000-0001-6341-7979)
- Zhifa Zheng (ORCID: https://orcid.org/0009-0007-8265-3724)
- Su Liu (ORCID: https://orcid.org/0000-0002-5377-6369)
- Fei Liu (ORCID: https://orcid.org/0000-0003-0064-7827)
- Jing Hao (ORCID: https://orcid.org/0000-0003-3851-0340)
- A -N Liang
- Zhihong Wu
- Lina Zhao
- Lijin Liu
- Wei Zou
- Ze Wei
- Wenjing Ma
Institutions
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Peking Union Medical College Hospital (CN)
Publication Details
- Journal
- International Journal of Rheumatic Diseases
- Published
- 2026-01-28
- DOI
- https://doi.org/10.1111/1756-185x.70447
- Primary Topic
- Osteoarthritis Treatment and Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.00