Reactive Infectious Mucocutaneous Eruption (RIME) in an Adult: A Case Report

In our case—a 39-year-old adult with severe oral and ocular mucositis, pharyngeal ulceration, and confirmed M. pneumoniae co-infection with Rhino/Enterovirus—early initiation of systemic corticosteroids, alongside targeted antibiotic therapy, facilitated rapid improvement and recovery. The presentation aligned with RIME’s distinguishing features and highlights the importance of timely diagnosis and differentiation from SJS/TEN and other diseases such as HIV or Syphilis to avoid unnecessary discontinuation of medications or over-treatment.