Neuropathological links between plasma p-Tau 181, white matter hyperintensity, and structural brain changes in aging
Severe WMH is associated with caudate nucleus enlargement. WMH may partially mediate the association between elevated plasma p-Tau 181 and caudate nucleus enlargement, suggesting a mixed pathology in the aging process of the brain, and highlighting the importance of early vascular risk control.
Authors
- Bing Bai (ORCID: https://orcid.org/0000-0003-4432-8019)
- Huiquan Yang (ORCID: https://orcid.org/0009-0008-6980-8792)
- G. Liu
- Wen Zhang (ORCID: https://orcid.org/0000-0001-5166-0736)
- Hao Wang (ORCID: https://orcid.org/0000-0001-6881-9977)
- Xiang Li
- Xin Li
- Bing Zhang
- Zhengyang Zhu
- Jiaming Lu
- Liangpeng Wei
- Xin Zhang
Institutions
- China Pharmaceutical University (CN)
- Nanjing Brain Hospital (CN)
- Nanjing Drum Tower Hospital (CN)
- Nanjing University (CN)
Publication Details
- Journal
- Quantitative Imaging in Medicine and Surgery
- Published
- 2026-01-28
- DOI
- https://doi.org/10.21037/qims-2025-376
- Primary Topic
- Neurological and metabolic disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00