Incidence Trends of Cutaneous Squamous Cell Carcinoma, Carcinoma In Situ, and Keratoacanthoma By Sex, Age, and Anatomical Site

In this nationwide cohort study presenting the most comprehensive dataset of incident cSCC, CIS, and KA, with 109 787 histologically confirmed patient cases, covering nearly 2 decades and spanning across all Danish health care sectors, incidence of cSCC and CIS continued to rise, consequently affecting more people, and sex differences diminished. Stabilizing trends in individuals younger than 50 years may indicate early prevention effects. Findings of this study have the potential to influence future surveillance activities and clinical care through attention to sex, age, and anatomical site.