Polyethylene glycol-coated patch versus standard dural sealing practices for preventing cerebrospinal fluid leaks in posterior fossa surgery: a randomized multicenter study

The PEG-coated patch, alone or with fibrin sealant, demonstrated comparable efficacy in preventing CSF leak compared to multiple product combinations. The study does not demonstrate superiority, but shows a reassuring safety profile and similar rates of secondary outcomes, including pseudomeningocele, hospital readmissions, surgical site infections and adverse events, in both groups. These findings support the PEG-coated patch as a safe dural sealing option in elective non-traumatic posterior fossa surgery, while potential workflow or economic advantages remain to be formally evaluated in future studies.

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Publication Details

Journal
Neurochirurgie
Published
2026-01-28
DOI
https://doi.org/10.1016/j.neuchi.2026.101777
Primary Topic
Head and Neck Surgical Oncology
Type
article
Field-Weighted Citation Impact
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article

Polyethylene glycol-coated patch versus standard dural sealing practices for preventing cerebrospinal fluid leaks in posterior fossa surgery: a randomized multicenter study

María Pérez Pérez, Laura Beatriz Lopez Lopez, Adan Fernandez Canal, L. Ley et al.
Neurochirurgie
Head and Neck Surgical Oncology
article

Polyethylene glycol-coated patch versus standard dural sealing practices for preventing cerebrospinal fluid leaks in posterior fossa surgery: a randomized multicenter study

María Pérez Pérez, Laura Beatriz Lopez Lopez, Adan Fernandez Canal, L. Ley, J.C. Rial Basalo, Alberto Acitores Cancela, Jorge Díaz Molina, Carlos Alberto Rodríguez Arias, Yaiza Lopez Ramirez, Luis González Martínez, Jose Manuel Ortega, Carmen Tudela Ataz, Jorge Bernal Piñeiro, Cristina Barcelo López, Patricia López Gómez, Cristina Ferreras, Rubén Martín Laez, Belén Álvarez, Sofía Sotos Picazo
article en

Abstract

The PEG-coated patch, alone or with fibrin sealant, demonstrated comparable efficacy in preventing CSF leak compared to multiple product combinations. The study does not demonstrate superiority, but shows a reassuring safety profile and similar rates of secondary outcomes, including pseudomeningocele, hospital readmissions, surgical site infections and adverse events, in both groups. These findings support the PEG-coated patch as a safe dural sealing option in elective non-traumatic posterior fossa surgery, while potential workflow or economic advantages remain to be formally evaluated in future studies.

NeurochirurgieVol. 72(2)
Marqués de Valdecilla University Hospital (ES), Hospital Universitario de Getafe (ES), Hospital Universitario Miguel Servet (ES), Hospital Universitario Central de Asturias (ES), Hospital Universitario Virgen de la Arrixaca (ES), Hospital Clínico Universitario de Valladolid (ES), Hospital Universitario Ramón y Cajal (ES)
Openalex Percentile: Top 75%
Head and Neck Surgical Oncology
DOIOpen Access PDFOpenAlex
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